A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief)

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A randomized, double-blind study of hydromorphone hydrochloride extended-release tablets versus oxycodone hydrochloride extended-release tablets for cancer pain: efficacy and safety in Japanese cancer patients (EXHEAL: a Phase III study of EXtended-release HydromorphonE for cAncer pain reLief)

BACKGROUND In Japan, there are limited options for switching opioid analgesics. Hydromorphone is an opioid analgesic that is routinely used instead of morphine for cancer pain; however, it is not yet available in Japan. The aim of this study was to assess the efficacy and safety of hydromorphone (DS-7113b) extended-release tablets in opioid-naïve patients with cancer pain not relieved by non-op...

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Clinical application of extended-release hydromorphone for pain management

Hydromorphone is a semi-synthetic μ-agonist commercially available in oral, rectal and injectable formulations for the control of acute and chronic pain [1]. Hydromorphone is typically used for moderate-to-severe pain, and is an effective alternative to morphine [1]. Like other μ-agonists in the opioid family there is no ceiling effect for hydromorphone, and cross-tolerance with other opioids i...

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ژورنال

عنوان ژورنال: Journal of Pain Research

سال: 2017

ISSN: 1178-7090

DOI: 10.2147/jpr.s136937